Resident Evil 2: All 2nd Run Scenario Differences

All Differences in Resident Evil 2’s 2nd Run Scenarios

Resident Evil 2 starts out by giving you a choice of Leon or Claire’s story. Whichever you choose, you’ll play through their first scenario, with the 2nd Run scenarios for each character unlocking once you’ve completed a playthrough for either character. Here’s what the differences in Resident Evil 2‘s 2nd Run scenarios are.

Sadly, we’ve actually got to tell you this time around that Resident Evil 2’s B scenarios don’t actually change a whole lot from what you experienced in the A scenarios in terms of gameplay content.

Upon beating the game once, New Game 2nd Run will be available for each character. This only changes a few things, which we’ve broken down for you below.

• A different opening cutscene.
• Different puzzle solutions.
• Shuffled item placements.
• Different ending cutscene.
• Scarcer Ammo.

Essentially, you’re going to get a slightly different look at how either Claire or Leon’s story starts and ends in a 2nd Run playthrough of Resident Evil 2.

In terms of how much these vary? Well, it’s a fair bit, with Claire’s putting you in control of her running through the courtyard as we saw in Leon’s 1st run, rather than entering the police department through the front.

If you play Claire’s 1st run, however, you’ll find that she largely follows the same steps as Leon for the first third of the game. The same applies for the different ending cutscenes. Essentially, if you want the ‘full picture’ of Resident Evil 2, you’ll want to check out the 2nd Run scenarios for both Leon and Claire.

The other two changes to the 2nd Run scenarios in Resident Evil 2 are fairly self-explanatory. Puzzle solutions have now been changed a little just to keep you on your toes. For example, those generator switch puzzles now have different solutions in a 2nd Run scenario, and if you thought you knew the locations of items inside-out, guess again.

2nd Run scenario changes those, too, meaning you’ll have to essentially search and remap the entire Police Station (and subsequent locations) in your head for these playthroughs if you’re wanting to speedrun them, too.

On top of that, from our experience, ammo is far less frequently just lying around for you to pick up in a 2nd Run compared to the 1st Run scenarios.

As such, you’ll need to be far more conservative with unloading shots into enemies. Our tip is to only kill enemies that are in rooms you need to spend a fair amount of time in solving puzzles in.

That’s all you need to know regarding all 2nd Run scenario differences in Resident Evil 2. If we come across any others, we’ll be sure to update this post and let you know.

For more tips, tricks, and guides for surviving the nightmarish Raccoon City, be sure to check out our ever-expanding Resident Evil 2 guide wiki.