Enigma of Sepia Tier List – Best Heroes Ranked (February 2025)

There are 44 heroes available at the global launch of Heroes of Sepia. Each unit carries its special traits, but many of them are united by personal synergies, so make up your party accordingly. In this guide, we’ll provide you with the Enigma of Sepia tier list, ranking every single unit by strength.

All Heroes Tier List for Enigma of Sepia

SS-Tier Enigma of Sepia Heroes

These are the most overpowered heroes in the game, who can stand on their own or be the best leaders in each of their respective parties, especially Sanguina, having the top damage among all other units.

Heroes	Attributes	Stats
Sanguina	· Best true damage dealer and slayer in the game. · Increases chances of instantly killing enemies. · Automatically activates counterspell every time she defeats an enemy.	ATK: 634,149 HP: 4,436,207 DEF: 129,083 SPD: 2,952
Chronis	· Best curser and buffer unit in the game. · Gains free Blood Rage when playing alongside Carmilla. · Increases the chance of delaying enemy attacks. · Applies Time Stop to all enemies.	ATK: 631,533 HP: 4,418,056 DEF: 128,522 SPD: 2,940
Satoria	· Best AoE damage dealer in the game. · Applies counterspell buffs to all allies under conditions. · Applies Time Stop to all enemies. · Automatically activates counterspell every time she defeats an enemy.	ATK: 631,533 HP: 4,418,056 DEF: 128,522 SPD: 2,940
Sepia	· Best control unit that is capable of dealing true damage. · Gains multiple stacks of self-healing. · Increases chances of instantly killing enemies.	ATK: 605,076 HP: 4,233,390 DEF: 123,099 SPD: 2,759

S-Tier Enigma of Sepia Heroes

The following units may not be as overpowered as the top-tier ones, but they have highly useful skills and solid damage output, which puts them on the top shelf of our Enigma of Sepia tier list.

Heroes	Attributes	Stats
Vespera	· Solid AoE damage dealer and purifier unit. · Guarantees applying Severe Wound to enemies under Transcendence. · Increases chances of instantly killing enemies.	ATK: 602,445 HP: 4,214,978 DEF: 122,564 SPD: 2,747
Yukari	· Great control unit with sacrifice mechanics. · Guarantees 100% Taunt success against despair targets. · Increases chances of inflicting Fire Curse on the random target.	ATK: 602,353 HP: 4,215,092 DEF: 122,632 SPD: 2,747
Erenor	· Best line unit and debuffer in the game. · Gains 5 stacks of Wave against vanquished targets. · Applies 3 extra stacks of Vanquished to entangled enemies.	ATK: 602,353 HP: 4,215,092 DEF: 122,632 SPD: 2,747
Nova	· Solid AoE damage dealer with the Thump mechanic. · Increases the chance to apply Severe Wound to certain enemies. · Gains free Blood Rage when playing alongside Carmilla.	ATK: 494,477 HP: 3,460,275 DEF: 100,515 SPD: 2,184
Little Rasi	· Solid AoE damage dealer with the Thump mechanic. · Increases chance to apply Severe Wound to certain enemies. · Gains free Blood Rage when playing alongside Carmilla.	ATK: 494,477 HP: 3,460,275 DEF: 100,515 SPD: 2,184
Lena Frost	· Excellent line unit with debuff abilities. · Applies 5 extra stacks of Soul Slash to enemies with Critique. · Has a significant impact on all energy consumption.	ATK: 494,477 HP: 3,460,275 DEF: 100,515 SPD: 2,184
Eclipsea	· Another fantastic AoE damage dealer with the Crow mechanic. · Applies a stack of Crow to all enemies if she scores a kill. · Applies 3 stacks of Crow to all electrified enemies.	ATK: 597,198 HP: 4,178,266 DEF: 121,496 SPD: 2,724
Lumina	· Very strong AoE counter damage attacker. · Applies 3 extra stacks of Blood Rage if the target is not wounded. · Increases chance to inflict Herme Seed under Blood Rage. · Negates Blood Rage cost against enemies inflicted with Time Stop.	ATK: 555,054 HP: 3,883,767 DEF: 112,873 SPD: 2,504
Carmilla	· Very strong AoE counter damage attacker. · Applies 3 extra stacks of Blood Rage if target is not wounded. · Increases chance to inflict Herme Seed under Blood Rage. · Negates Blood Rage cost against enemies inflicted with Time Stop.	ATK: 552,423 HP: 3,865,263 DEF: 112,355 SPD: 2,492

A-Tier Enigma of Sepia Heroes

Here’s the last batch of good party leaders that require very few conditions in Enigma of Sepia to be highly effective on the battlefield. It’s still recommended to pair them up with their synergistic partners for better performance, such as Morgana and Giselle.

Heroes	Attributes	Stats
Aqua Sera	· Good buffer with solid AoE capabilities. · Applies Idle Speed on enemies inflicted with 3 stacks of Wave. · Gains 5 stacks of Wave against vanquished enemies.	ATK: 486,585 HP: 3,405,049 DEF: 98,911 SPD: 2,149
Celestia	· Another good buffer with AoE skills. · Increases chances to apply Banishment after a successful critical hit. · Instantly kills targets with less than 25% of HP.	ATK: 552,423 HP: 3,865,263 DEF: 112,355 SPD: 2,492
Giselle	· Best combo unit with transformation abilities. · Synergizes with Morgana. · Grants 5 extra stacks of Magical Circuit.	ATK: 549,808 HP: 3,846,965 DEF: 111,823 SPD: 2,480
Morgana	· One of the best supporter buffer units in the game. · Gains 5 extra stacks of Magical Circuit. · Increases the chance of delaying enemy attacks.	ATK: 549,808 HP: 3,846,965 DEF: 111,823 SPD: 2,480
Sandra	· One of the top healers in the game. · Automatically heals all allies under 20% HP. · Applies 3 stacks of regeneration to all allies with Rubber Rebound.	ATK: 547,104 HP: 3,828,645 DEF: 111,344 SPD: 2,468
Elysia	· Good debuffer with AoE capabilities. · Increases the chance to summon Twirling Orb against electrified enemies. · Applies 1 extra stack of Burn against 3 random targets.	ATK: 452,364 HP: 3,165,778 DEF: 91,929 SPD: 1,977
Sylphyra	· Solid combo buffer with some good control capabilities. · Applies 1 extra stack of Burn against 3 random targets. · Applies 1 stack of Crow if enemy was killed with the Wrath of the Storm God.	ATK: 505,047 HP: 3,534,002 DEF: 102,691 SPD: 2,255
Naldra	· One of the top burn characters that applies curses. · Synergizes with Eldwyn unit. · Increases chances to apply Oath Fire with Dragon Wings.	ATK: 505,047 HP: 3,534,074 DEF: 102,678 SPD: 2,255

B-Tier Enigma of Sepia Heroes

The following mid-tier units will be most useful in support roles as synergy partners for top leaders. Many of them perform well in the right party either in the middle or back row. But be sure to put healers in the very back, where they’ll be less threatened, such as Mentora and Scientia.

Heroes	Attributes	Stats
Nora Zorana	· Decent debuffer with average AoE skills. · Increases damage-healing conversion ratio if enemies are inflicted with debuff. · Synergizes with Nova unit.	ATK: 505,047 HP: 3,534,002 DEF: 102,691 SPD: 2,255
Crimson	· Applies curse effects with Leech skills. · Gains 3 stacks of Slaughter Aura. · Best against Protocol enemies.	ATK: 502,416 HP: 3,515,664 DEF: 102,143 SPD: 2,244
Denise	· Decent debuffer with electricity control. · Inflicts Chainsaw Storm on electrified targets. · Synergizes with Giselle.	ATK: 502,359 HP: 3,515,664 DEF: 102,200 SPD: 2,244
Ivy Lynn	· Another good healer with crowd-control capabilities. · Increases anger intensity after triggering the combo technique. · Increases Sepia’s healing effects for each stack fo Fate.	ATK: 499,744 HP: 3,497,366 DEF: 101,668 SPD: 2,232
Caelestis	· Solid defender with high damage resistance. · 100% chance to gain Rage Addict against exposed enemies. · Synergizes with Ayame.	ATK: 499,744 HP: 3,497,366 DEF: 101,668 SPD: 2,232
Bipolaris	· Another functional debuffer with curse abilities. · Inflicts Herme Seed and Severe Wound on enemies. · Good against Protocol enemies.	ATK: 497,170 HP: 3,478,956 DEF: 101,076 SPD: 2,220
Mentora	· Decent healer with shield abilities. · Heals 3 allies with the lowest HP. · Synergizes with Yurina.	ATK: 494,483 HP: 3,460,546 DEF: 100,598 SPD: 2,209
Scientia	· Another good healer with crowd-control capabilities. · Increases anger intensity after triggering the combo technique. · Increases Sepia’s healing effects for each stack of Fate.	ATK: 494,483 HP: 3,460,546 DEF: 100,598 SPD: 2,209

C-Tier Enigma of Sepia Heroes

This tier of heroes involves units that have, unfortunately, the lowest damage output in comparison to all others, excluding the basic ones. Even when synergized with other stronger heroes, their performance is very much lackluster.

Heroes	Attributes	Stats
Ginara	· Instant debuffer with curse effects. · Good only against enemies with Critique, Entangled, or Destiny effects.	ATK: 494,539 HP: 3,460,546 DEF: 100,541 SPD: 2,209
Eldwyn	· Decent puncher able to inflict bleeding effects. · Efficiency depends on low HP, increasing damage only if under 20% HP.	ATK: 462,942 HP: 3,239,945 DEF: 94,105 SPD: 2,045
Sylvia	· Subpar slayer with bleed effects. · Can instantly kill enemies, but only if they’re under 25-30% of HP.	ATK: 457,680 HP: 3,202,778 DEF: 93,035 SPD: 2,021
Dr. Lorena	· A rather weak healer, but synergizes with Nova for extra damage. · Heals all allies only if they’re under 20% HP.	ATK: 428,691 HP: 3,000,374 DEF: 87,149 SPD: 1,874
Ayame	· Low-damage AoE dealer with curse capabilities. · Damage increase depends on stacks of Wave.	ATK: 426,093 HP: 2,981,926 DEF: 86,590 SPD: 1,862
Eliza Thorn	· Another low-damage AoE dealer with curse capabilities. · Can instantly kill enemies, but only if they’re under 30% HP.	ATK: 423,463 HP: 2,963,559 DEF: 86,048 SPD: 1,851
Aurora	· Another low damage AoE dealer with curse capabilities. · Can instantly kill enemies, but only if they’re under 30% HP.	ATK: 420,832 HP: 2,945,151 DEF: 85,513 SPD: 1,839
Alfyria	· Weakest healer that carries shield. · Capable of penetrating enemy armor under special conditions.	ATK: 420,800 HP: 2,945,151 DEF: 85,545 SPD: 1,839

D-Tier Enigma of Sepia Heroes

Finally, our Enigma of Sepia tier list ends with the basic units that are available at the start of the game. These units should be used only in the early game and rerolled as soon as possible for much stronger units listed above.

Heroes	Attributes	Stats
Little Sai	· Basic AoE damage dealer. · The strongest early game unit with Teleportation skill.	ATK: 1,610 HP: 10,496 DEF: 416 SPD: 207
Lyra	· Basic unit for countering attacks. · Capable of negating damage.	ATK: 685 HP: 4,442 DEF: 222 SPD: 164
Royelle	· Basic curse unit with some AoE skills. · Capable of penetrating enemy armor under special conditions.	ATK: 744 HP: 4,319 DEF: 252 SPD: 225
Levia	· Basic supporter unit, increasing rage skill. · High-speed debuffer for early game.	ATK: 673 HP: 4,010 DEF: 220 SPD: 189
Yurina	· Early game tank with Taunt ability. · Has some good damage resistance skills.	ATK: 640 HP: 4,025 DEF: 239 SPD: 186
Cheshire	· Basic unit that’s good against electrified enemies. · Mostly used for debuffing enemies in the early game.	ATK: 608 HP: 3,756 DEF: 181 SPD: 154
Mirage	· Weakest AoE damage dealer in the game. · Has access to a few buff skills for early game.	ATK: 606 HP: 3,747 DEF: 180 SPD: 153

That’s it for our Enigma of Sepia tier list guide. For more, check out Legend of Mushroom Tier List and Civilization 7 Tier List. We’ve also got All Stellaris Console Commands and How to Use Them and Top 70 Best Skyrim Mods for Xbox.