Adam and Eve
Adam and Eve were hybrid creations, more advanced than the other humans at the time because they could not be controlled by the Pieces of Eden. It is hinted that this is due to genetic mutation from interbreeding of humans and Precursors, but for whatever reason, Adam and Eve were born without the neurotransmitters in their brains.
Eventually, Adam and Eve became angered by their enslavement, realizing that the Precursors were not gods. They stole one of the Pieces of Eden, which is also referred to as the Apple of Eden, and escaped the confines of Eden.
The exact chain of events after that is not clear, but shortly after, war broke out between the Precursors and the humans. The humans, being a rebellious species that demanded freedom at any cost, went into battle against the Precursors to end their enslavement. Though the Precursors were more advanced, the humans were numerous and adaptive, making the war a difficulty to fight on both sides. However, this war between the humans and the Precursors came at the worst time possible, paving way for the collapse of The First Civilization.