Separating Agents are Your Friends – Madhouse Difficulty Tips
Remember that whole horde of separating agents you collected in your first playthrough but never got around to using? Well, you’re certainly going to be using them a lot in Madhouse mode. The separating agents can be used on items like first aid meds, handgun ammo, and burner fuel to obtain raw materials and, more importantly, chem fluid. By using the separating agents on items that you don’t immediately need, you can make use of the chem fluid to craft something that you do need at that point in time.
Since there’s a limited number of these in Resident Evil 7, you should always try to make sure that you have a balanced supply of healing items and ammunition at all times. Save your separating agents for the direst of situations when you’re completely out of health or ammo. It’s also recommended that you try to use the separating agents to obtain strong chem fluid. These can be used to craft enhanced handgun ammo, which can prove to be extremely powerful when used correctly.