Fallout 4: How to Beat the Mirelurk Queen

If you summoned the Vertibird before triggering the Queen, make a dash for the minigun on the chopper the second it lands. This is what you’ve been saving your Critical Strike for. Use the minigun and aim for her face (her weak spot) in V.A.T.S, and use the Critical Strike for extra damage. Even after blowing through the Critical Strike, multiple minigun shots to the face while on the Vertibird will deal severe damage to her. If you don’t have access to Vertibird support, just a normal minigun will do the trick as well, though you’ll have to watch your ammo reserves.