Let symptoms develop on their own at first
Initially, you’ll want to keep your pathogen as low-profile as possible. This will keep your fungus from appearing on watchlists worldwide, increasing the chances of infected patients visiting other countries through the aforementioned transmissions. Infected or frightened countries may shut down their borders, forcing you to rely on other forms of transmissions to infect them.
As Plague Inc. progresses, symptoms for your disease will gradually develop on their own. Whatever its naturally evolved symptoms may turn out to be, you can build upon that later to increase the deadliness of your fungus. This can range from simple insomnia and coughing to all-out insanity and hemorrhagic shock, depending on how lucky you get in that specific match.
While symptoms don’t require too many DNA points at first, it’s better to spend these precious points on transmissions to ensure the maximum amount of DNA points you can harvest from red infection bubbles and orange DNA bubbles. It may be tempting to experiment with symptom combinations when you have 80+ DNA points stacked, but that experimentation is better left for some easier pathogens in the game, such as viruses or bacteria.