Bring Nick Valentine
To be honest, you should take Nick Valentine everywhere simply because he’s possibly the coolest companion in the whole game. But the real reason you should bring Nick along for the Nuka-World ride is because he’s a Synth and they’re immune to silly things like radiation, which is something you’ll come across a lot in Fallout 4’s latest expansion. Bethesda held nothing back this time around, so you can expect to see a lot of bullets, laser blasts and, and radioactive waves headed your way. There also seems to be a lot more “glowing” enemies this time around too, and it manages to put Far Harbor’s irradiated Maine to shame.
If you don’t want to bring Nick alone for whatever reason, at least bring one of Automatron’s robots along for the journey. They can be customized more to your liking, with weapons and skills that rival any of your other companions. On top of that, these suckers can carry a whole lot more junk. You’re going to find a lot of interesting things to scavenge, so let’s not leave anything behind, okay?
If for some reason you feel that a living, breathing companion is better suited for the adventure, consider Hancock or Strong. While both will suffer greater from explosive and ballistic damage when compared to Synths or robots, they’re also both immune to radiation. It’s best to have someone who will survive than it is to have someone whose company you enjoy.