Batgirl
Barbara Gordon was the first of many Batgirls. A gymnast and genius, her career as an able-bodied superhero was cut short when the Joker shot and paralyzed her from the waist down. But Babs didn’t let this get her down and became a technical savant under the identity of Oracle. The impact she’s left on comics is such that DC has let Oracle live on in other universes, despite Barbara being able to walk in the New 52.
In their recent Future’s End comic event, readers were treated to a future where Batgirl had a League of Batgirls of her own–Stephanie Brown, Cassandra Cain, and Tiffany Fox. Merging Future’s End with the classic DC universe where Babs is Oracle would be an acceptable way to acknowledge both continuities. Start the game off years prior to her crippling before jumping ahead in time. Each Batgirl has their own skills and abilities–Cass can take more pain and can see weak points in an enemy, Tiffany’s a master hacker, and Stephanie has a function in her suit that allows her to go invisible for a short time. Alternate between the characters each chapter before bringing them together to take down the Big Bad. Or do GTA V-style and switch between them in real time with the press of a button.