4. Cesare Borgia – Assassin’s Creed Brotherhood
The biggest reason Cesare Borgia is such an imposing villain is because of how he puts Ezio on the defensive, destroying the assassin’s home base completely right off of the bat. In an interesting turn of events, Cesare seeks revenge on Ezio for killing his family and taking what he loved, the same reason Ezio hunted the Borgia to begin with. For most of Assassin’s Creed Brotherhood, the master assassin spends his time trying to catch up against the overwhelming power of Cesare and his army. It’s only with an entire brotherhood of fellow Assassin’s that Ezio can overcome his foe. Ultimately, the feud between the two comes to a head as they battle things out in a deadly sword fight in the middle of flames and destroyed buildings.