As Corvo
For those who performed a no kill run in the last Dishonored, then you will have a general idea of what should be picked up. Upgrading Blink should be your priority, as the increase in distance allows you to traverse rooftops and scaffolding easier. Unlike Far Reach, there is no carry of momentum, so don’t worry about being flung into a group of guards on accident.
The next skill you should grab is Bend Time; it is incredibly handy when you need to either neutralize a group of enemies or pass by them. Unlike Domino, you will need to manually hit each target with a sleeping dart, which isn’t ideal when you can only carry five. Once you’ve upgraded it to stop time entirely, you can use this to knock out one target at a time. Just make sure to hide the bodies away between Bend Time usages, otherwise you will be stuck out in the open with a knocked out guard over your shoulder.
Finally, Possession and Dark Vision should be the last two you pick up. They can offer Corvo some ways to sneak past guards without them noticing. There are a lot of vents in Karnaca, so feel free to take control of a rat and use them to traverse areas. You can also use Possession to take control of Guards, which will allow you to pass through areas such as the Wall of Light or by Tesla Coils.
Trying to obtain a no kill run is a challenge, but if you invest in the right powers and always stay alert then this shall be yours. Just make sure to place your knocked out bodies on solid surfaces, otherwise they can slide right off an die easily. Remember to visit our ever-expanding Dishonored 2 wiki for all your tips, tricks, guides, and trophy and achievement walkthroughs.