Side Missions Are Pretty Much Mandatory
Side missions in Borderlands 3 aren’t required for story progression, but we strongly recommend knocking them out whenever you come across them, especially when you get to Promethea, which is the second planet you’ll visit.
The story missions in Borderlands 3 actually amp up the level recommendations pretty quickly, and it’s definitely not advisable for players to tackle missions that are three levels higher than they are. This usually results in a pretty bad time and lots of party wipes.
Side missions in this game are generally pretty fun and flavorful, and give you access to pretty good gear as long as you’re doing them at the right level. They also give you tons of experience, which will let you tackle the story missions at a comfortable pace.