Oddworld
While Oddworld Inhabitant’s library of Oddworld games is rather small, the franchise is consistent on two fronts. Oddworld games are consistently good and odd. If not for one particular entry, they also would consistently be puzzle platformers.
Oddworld: Abe’s Oddysee, for those who never heard of the game, is a 2D platformer that won numerous awards thanks to its oddball characters, puzzles, unique “Gamespeak” mechanic, and a powerful environmental message.
The sequel, Oddworld: Abe’s Exoddus, is more of the same but better. Even the third title, Oddworld: Munch’s Oddysee, faithfully translates the other games’ strengths into a 3D setting. However, the fourth game in the Oddword franchise, Oddworld: Stranger’s Wrath, is a stark contrast as it eschews puzzle platforming for first-person shooting.
Instead of jumping between platforms, recruiting and rescuing NPCs, the game’s protagonist (the titular Stranger) bags criminals dead or alive. Oh, and he fires live ammunition (literally live, as in fuzzy animals and insects) from a wrist-mounted crossbow.
I would say that odd doesn’t begin to describe Stranger’s Wrath’s change in genres, but odd always has been Oddworld’s bread and butter.