Overwatch
When Blizzard announces it’s tackling a genre, the world listens. The hype for Blizzard’s take on the shooter genre, Overwatch, was massive. To this day it’s one of the most popular games in the world. Just imagine if they took the same lineup of characters and tossed them into a fighting spinoff.
They absolutely have enough memorable characters with wildly diverse movesets. I have to imagine that Tracer would be one of the top-tier characters just because of her speed. Sombra would also be amazing with her teleporter and the ability to stop your opponent from using specials.
Characters like Roadhog, Reinhardt, and Doomfist already have a moveset filled with physical attacks and projectiles that would easily translate to a fighting game. Blizzard seems to usually start from the ground up with new genres, but an Overwatch fighting spinoff would be incredible.