Uncharted
Uncharted really seems like an obvious choice, seeing as Uncharted is basically Indiana Jones, which has already been adapted as a LEGO game twice before. In all seriousness, the vibrant and beautiful locations featured in the Uncharted games just beg for a LEGO rendition, and the gameplay mechanics wouldn’t be difficult to replicate either. Cover-based shooting has been done in LEGO titles before, and things like a climbing mechanic unlike the typical platforming style of LEGO games would be easy to set up.
The LEGO game could cover the first three main titles, while a potential second game could include the recently released fourth installment alongside all the spin-offs that have been added to the franchise since (Golden Abyss was pretty damn good, after all). Plus, miniature Nate and friends would be so cute!