The Suicide Mission – Mass Effect 2
Okay, this may be cheating as this was a series of choices, but the overall goal of all of these decisions is the same: stop the Collectors and make sure Shepard’s entire team gets out alive.
Players must make several decisions, assigning different characters to everything from who to lead each fire squad to who should escort the Normandy survivors back to the ship. There’s a lot to get through in a short amount of time, and the pressure is intense. A wrong choice might lead to squad mates losing their lives and erasing them from the narrative. For this mission, Mass Effect 2 activated a permadeath system (only for the choices, thankfully, not the gameplay), so any teammate lost in this section of the game could not be brought back. The pressure of the moment and the threat of losing a valued companion made this a particularly nerve-wracking moment in the series.