Mass Effect
What kind of card game could Mass Effect bring? If you’re looking for a diverse group of characters, Mass Effect is your game. There are many races that inhabit citadel space and many smaller groups and organizations within many of those races. In addition, there’s lots of tension and disdain between certain races; some kind of mini-game could play off of this.
Make the stakes high for this card game. After all, you’re traveling around the galaxy. There could be a galactic tournament where the greatest players come together to grapple their way to the top. These players can be the rich and wealthy and maybe the prize pool involves winning your own star system or planet. With how interconnected everything in the Mass Effect universe is, it certainly isn’t stretching things to see a card game evolve to be everyone’s favorite, universal pastime.