Link
Imagine an entire season of Doctor Who with a silent hero. What would his counterparts do? They’d have to learn how to read his nonverbal communication, figure out how to play songs on an Ocarina, and carry around a lot of bottles with potions and fairies. And somehow the writers would work Ganondorf into the plot, because Link doesn’t really have any other enemies in life.
Crono
From the Dark Ages to a post-modern dystopia, Crono has triggered all kinds of events through time, and he did so with grace. He’d make a great Doctor, and Lucca would be the perfect co-star. Resolving the conflicts of the plotlines might come too easy for them, actually.
Solid Snake
Snake? Snake? Yes, Snake! There’s nothing fantastical about the man, but the number of battle wounds he gets to wear as badges far outnumbers any other Doctor candidate. The only time it got weird for him was when he had to switch to the Player 2 slot on his original PlayStation.