One Punch Man
Okay, so One Punch Man may not seem like it’s set up for a really great video game. Here you have a hero, Saitama, who can destroy pretty much every foe with just a single punch. And it’s not that he just knocks them out or something, they explode into pretty visceral bits. Being that powerful is pretty odd, effectively giving you “god mode” throughout the entire game, but it can be done.
Take a game like Dynasty Warriors, where the screen is filled to the limit with thousands of enemies for you to fight through as you endeavor to save the world, while also looking for a fitting challenge. Your ability to put the weight of everyone’s worry on yourself, and strength to fight through it would be a driving force of the game, as would be the top-notch humor that only Saitama’s emotionless face can bring.