Who Counters Sombra
Winston
This lovable gorilla is currently the hero we see best in taking on Sombra currently. His tesla cannon can very quickly suss out Sombra trying to sneak by with invisibility, and even if hacked, he can continue to deal significant damage and take her down. The loss of his deployable barrier and leap could be a problem if faced with uneven numbers, but for a one-on-one duel, Winston has the upper hand.
Mei
Mei would be similarly effective against her, as her ice stream could be continuously used to weed out an invisible Sombra in the mix. And once devoid of her sprinting and also slowed by Mei’s ice, she is very quickly out of options to get away beyond a hail-mary teleporter throw. And if Mei can freeze her solid, she can finish her off with a single icicle to the noggin. That said, a hacked Mei would have to be careful with her health bar and count on freezing her to win a one-on-one.