10. Fighting Your First Big Sister – BioShock 2
One of the new additions to BioShock 2 was the slender and more powerful Big Sisters who would appear after a player dealt with a certain amount of Little Sisters. You have a brief encounter with one early on in the first chapter, but it’s not until a little bit later that you get your first real taste of combat with these acrobatic powerhouses. Before the fight begins you will hear their screeches ring out while warning signs pop up on the screen and let you know one’s on the way.
This is not only an intimidating start, but the fights themselves are incredibly difficult thanks to the Little Sisters’ ferocious attack style. While laying out some traps with your Rivet Gun may help turn the tide, there will always be something nerve-wracking about hearing that first screech as one closes in on you.