Is Agents of Mayhem in Another Universe?
Saints Row 4 ended with the Third Street Saints as the last humans in the galaxy, give or take a Jane Austen. The Earth is destroyed, but they’re effectively rulers of the Zin Empire, cementing themselves as basically the most powerful beings on the face of the galaxy. They’re the textbook definition of “Started from the bottom, now we’re here”.
Obviously, there’s no real way to continue the adventures of the Saints, now that they’ve got an entire galactic army behind them, unless Volition decided that they should try and fight cosmic entities. Their story has effectively been wrapped up, even taking into consideration the extra ending where they make plans to travel to other planets and take them over. A complete, wipe the slate clean reboot would just be unfair, so the next big thing could be an alternate universe.
Having Agents of Mayhem be an alternate version of the Saints would allow for Volition to continue the series in spirit without stepping on their own toes. There are still elements from the Saints series that carry over; the zippy dialogue, the comically evil supervillain, the banter between the three leads, and not to mention the return of the Ultor Corporation. The explanation that this is all basically the Earth-2 equivalent of the Saints’ origin story would explain why the Agents’ logo looks very much like the Saints’. Maybe it, like Ultor’s appearance here, is one of those eternal constants across the multiverse, much like Uncle Ben dying.