Fallout 4 has a lot of perks for players to choose from (70 to be exact). And some of those perks have Ranks that unlock even more sub-perks. But not all perks are created equal. There are those that transcend the simple act of just increasing a particular stat and really open up the possibilities of Fallout 4.
These are the creme de la creme of what the Wasteland has to offer a Vault Dweller out on an adventure. Some of these perks will require heavy investment into a specific tree (you can give yourself a head start when setting your stats at the very beginning), so getting all of these on one character will take some time. But it will definitely be worth it.