The Witcher 3: Hearts of Stone introduces the all new Runewords and Glyphwords mechanic to the game through a brand new craftsman; the runewright. This fellow is able to enchant your weapons and armor in ways that a basic runestone or glyph couldn’t hope to do. There are a lot to choose from, and some only become available once the runewright has reached a certain level.
To acquire the runewright you must complete his questline. After that you can increase his level up to Master Craftsman by investing in his shop. 10,000 Crowns gets him to advanced, and an additional 15,000 makes him a master.
The enchantments are broken down into two categories. Runewords are for weapons, and Glyphwords are for armor.