There’s nothing more fun than finding video game references in TV shows. If you watch Adventure Time or Steven Universe, the references come every other episode or so, and they’re usually referencing classic titles like Final Fantasy or Sonic the Hedgehog.
My Little Pony: Friendship is Magic loves dropping references as well, whether it’s to Bioshock Infinite, or more recently, Metal Gear Solid. The second season’s 20th episode had Twilight Sparkle dress in a stealth suit, eyepatch, and headband and recreate the “I’m a statue!” moment from Metal Gear Solid 4. In their more recent episode, they just went for one on the nose, having Discord (voiced by John de Lancie) pop out of a box with an exclamation point appear over his head. Not subtle, but still pretty funny.
Maybe Kojima will see this an include the ponies as a player skin for Metal Gear Solid 5. After all, the ponies have clearly got the gear, so might as well, right? Can start a new franchise, and the MLP creators would probably help out with it!